Metabolic engineering strategies for microbial synthesis of oleochemicals
نویسندگان
چکیده
منابع مشابه
Microbial engineering for aldehyde synthesis.
Aldehydes are a class of chemicals with many industrial uses. Several aldehydes are responsible for flavors and fragrances present in plants, but aldehydes are not known to accumulate in most natural microorganisms. In many cases, microbial production of aldehydes presents an attractive alternative to extraction from plants or chemical synthesis. During the past 2 decades, a variety of aldehyde...
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Improvements in the biological production of 1,3-propanediol, a key component of an emerging polymer business, have been realized. Utilizing genes from natural strains that produce 1,3-propanediol from glycerol, metabolic engineering has enabled the development of a recombinant strain that utilizes the lower cost feedstock D-glucose. This accomplishment bodes well for future metabolic engineeri...
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As the focus of microbial metabolic engineering shifts to include bulk commodities, two aspects of this research have become increasingly important. One is the requirement for high production titers in order to make the process economically viable. The second is to engineer microbes that are tolerant to these target products, many of which are toxic to cell growth. This review focuses on recent...
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MOTIVATION Although constraint-based flux analysis of knockout strains has facilitated the production of desirable metabolites in microbes, current screening methods have placed a limitation on the number knockouts that can be simultaneously analyzed. RESULTS Here, we propose a novel screening method named FastPros. In this method, the potential of a given reaction knockout for production of ...
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ژورنال
عنوان ژورنال: Metabolic Engineering
سال: 2015
ISSN: 1096-7176
DOI: 10.1016/j.ymben.2015.01.009